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Index > Protein center > KIR2DL3(Gene name) > Human
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  • KIR2DL3 (Gene name),
  • Killer cell immunoglobulin-like receptor 2DL3 (Protein name ),  KI2L3_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    KIR2DL3(CD158B2;KIRCL23;NKAT2);
    Protein name:
    Killer cell immunoglobulin-like receptor 2DL3;
    Alternative:
    KIR-023GB;CD158 antigen-like family member B2;MHC class I NK cell receptor;Killer inhibitory receptor cl 2-3;NKAT2b;NKAT2a;p58 natural killer cell receptor clone CL-6(p58 NK receptor CL-6);Natural killer-associated transcript 2(NKAT-2);p58.2 MHC class-I-specific NK receptor;
    CD:
    CD158b2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ARRB2.
    Function:
    Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    341
    Sequence:
    50:
    MSLMVVSMVC | VGFFLLQGAW | PHEGVHRKPS | LLAHPGPLVK | SEETVILQCW | 
    100:
    SDVRFQHFLL | HREGKFKDTL | HLIGEHHDGV | SKANFSIGPM | MQDLAGTYRC | 
    150:
    YGSVTHSPYQ | LSAPSDPLDI | VITGLYEKPS | LSAQPGPTVL | AGESVTLSCS | 
    200:
    SRSSYDMYHL | SREGEAHERR | FSAGPKVNGT | FQADFPLGPA | THGGTYRCFG | 
    250:
    SFRDSPYEWS | NSSDPLLVSV | TGNPSNSWPS | PTEPSSETGN | PRHLHVLIGT | 
    300:
    SVVIILFILL | LFFLLHRWCC | NKKNAVVMDQ | EPAGNRTVNR | EDSDEQDPQE | 
    341:
    VTYAQLNHCV | FTQRKITRPS | QRPKTPPTDI | IVYTELPNAE | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    String:
    MIM:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Killer cell immunoglobulin-like receptor 2DL3
    Cat.:
    E10468h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Killer cell immunoglobulin-like receptor 2DL3
    Cat.:
    U10468h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Killer cell immunoglobulin-like receptor 2DL3
    Cat.:
    P10468Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Killer cell immunoglobulin-like receptor 2DL3
    Protein for Human Killer cell immunoglobulin-like receptor 2DL3

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
      Colonna M. , Samaridis J.
      Science268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Natural killer cell.
    2. 2.
      "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
      Wagtmann N. , Biassoni R. , Cantoni C. , Verdiani S. , Malnati M.S. , Vitale M. , Bottino C. , Moretta L. , Moretta A. , Long E.O.
      Immunity2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Natural killer cell.
    3. 3.
      "Alternatively spliced forms of human killer inhibitory receptors."
      Doehring C. , Samaridis J. , Colonna M.
      Immunogenetics44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS LEU-229; THR-304 AND HIS-318
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1);VARIANTS ALA-9; ARG-32; GLU-56; ARG-71 AND HIS-318
    5. 5.
      "Polymorphism and domain variability of human killer cell inhibitory receptors."
      Selvakumar A. , Steffens U. , Dupont B.
      Immunol. Rev.155:183-196(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-9; ARG-32; GLU-56; ARG-71; ILE-242 AND HIS-318
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS LEU-229 AND HIS-318
      tissue: Blood.
    7. 7.
      "Genomic organization of a human killer cell inhibitory receptor gene."
      Wilson M.J. , Torkar M. , Trowsdale J.
      Tissue Antigens49:574-579(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298 (ISOFORM 1);VARIANT LEU-229
    8. 8.
      "Genomic organization of novel genes encoding human killer inhibitory receptors."
      Chae J.H. , Kim Y.M. , Ahn J.M. , Kim C.G. , Kim J. , Kim S.J. , Park J.H.
      Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341;VARIANT GLN-34
      tissue: Placenta.
    9. 9.
      "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
      Yu M.-C. , Su L.-L. , Zou L. , Liu Y. , Wu N. , Kong L. , Zhuang Z.-H. , Sun L. , Liu H.P. , Hu J.-H. , Li D. , Strominger J.L. , Zang J.-W. , Pei G. , Ge B.-X.
      Nat. Immunol.9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
    10. 10.
      "Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I."
      Maenaka K. , Juji T. , Stuart D.I. , Jones E.Y.
      Structure7:391-398(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-245
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